I've decided to cook healthier for my family, and that includes having more fish at home. After looking at easy tilapia recipes I decided to try baked tilapia. I love that it's fast, too! —Hope Stewart, Raleigh, North Carolina Tilapia fillets taste great baked in a mildly spiced tomato sauce, and covered with green peppers and onions. Just 35 minutes and six simple ingredients are all you need for this top-rated, flavorful tilapia recipe. Baked tilapia is delicious, and it is perfect for a healthy diet. With low carb side dishes, it makes an excellent choice for the low carb diet. How to Cook Tilapia in the Oven. Tilapia is a common white fish that absorbs flavors well when you cook with it. While you can always make tilapia in a pan, you can also bake it in your oven to fully infuse the flavors of other spices. You. How to bake tilapia: 1. Line a cookie sheet (with sides like these pans here) with foil. Spray with non stick spray. Season with your favorite seasonings. I really like lemon pepper seasoning best. Place tilapia on cookie sheet. 2. Preheat oven to 425 degrees and bake for about 15 minutes or until fish turns white and isn’t translucent anymore. Easy baked tilapia recipe. In this cooking video, Vickie demonstrates how to bake tilapia for a quick and easy main dish. Loading. Advertisement How to Bake Tilapia. Tilapia is a mild, white fish that is harvested in freshwater environments. The term tilapia is used to describe over 100 species of fish. Baking tilapia with seasonings can create both a healthy and quick meal. Preheat oven to 400°. Season tilapia with salt and pepper and place on a small baking sheet. Mix together butter, garlic, red pepper flakes, lemon juice, and zest then pour over tilapia. If you want to learn how to bake tilapia, you've come to the right place! We'll teach you how long to bake tilapia, including how long to bake tilapia at 450 degrees F. Plus, we're willing to share some of our favorite tilapia and fish recipes so you can cook your fish a different way for each night of the week.